所有图片(2)
别名:
细胞质动力蛋白抑制剂，Ciliobrevin D, 2-（7-氯-4-氧代-3,4-二氢喹唑啉-2（1H）-亚基）-3-（2,4-二氯苯基）-3-氧代丙腈，AAA+ ATPase运动细胞质动力蛋白抑制剂
经验公式（希尔记法）:
C17H8Cl3N3O2
推荐产品
product name
细胞质动力蛋白抑制剂，Ciliobrevin D, Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
质量水平
检测方案
≥99% (HPLC)
形式
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
orange
溶解性
DMSO: 2.5 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
O=C(C1=CC=C(Cl)C=C1N/2)NC2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)/C#N
一般描述
一种可渗透细胞的苯甲酰二氢喹唑啉酮衍生物，可作为AAA+ATPase运动细胞质动力蛋白的可逆和特异性阻滞剂，并以剂量依赖的方式破坏主轴极聚焦，冷稳定的微管形成，动粒微管附着和黑素体聚集（约10至40 µM）。 显示会干扰原纤毛内的蛋白运输，并导致原纤毛远端的鞭毛内运输蛋白88（IFT88）水平显著增加。据报道破坏了原纤毛依赖性Gli调节并阻断了刺猬信号传导。
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Hemalatha Muralidharan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(11), 2149-2165 (2022-01-21)
During neuronal migration, forces generated by cytoplasmic dynein yank on microtubules extending from the centrosome into the leading process and move the nucleus along microtubules that extend behind the centrosome. Scaffolds, such as radial glia, guide neuronal migration outward from
Chiara Cassioli et al.
Journal of cell science, 134(16) (2021-08-24)
Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co-opted by the non-ciliated T cell to orchestrate polarized endosome recycling and to sustain signaling during immune synapse formation. Here, we investigated the potential
Ambika V Nadkarni et al.
Cytoskeleton (Hoboken, N.J.), 78(10-12), 492-502 (2022-06-07)
Skeletal muscle differentiation occurs as muscle precursor cells (myoblasts) elongate and fuse to form multinucleated syncytial myotubes in which the highly-organized actomyosin sarcomeres of muscle fibers assemble. Although less well characterized, the microtubule cytoskeleton also undergoes dramatic rearrangement during myogenesis.
Chiara Cassioli et al.
Journal of cell science (2021-07-13)
Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co-opted by the non-ciliated T cell to orchestrate polarized endosome recycling and to sustain signaling during immune synapse formation. Here we have investigated the
Jung Hoon Cho et al.
Science advances, 8(38), eabq8486-eabq8486 (2022-09-24)
Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that primary cilia in human and mouse pancreatic islets exhibit movement that is
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