250401
Ciliobrevin D
≥99% (HPLC), powder, cytoplasmic dynein inhibitor, Calbiochem®
别名:
细胞质动力蛋白抑制剂，Ciliobrevin D, 2-（7-氯-4-氧代-3,4-二氢喹唑啉-2（1H）-亚基）-3-（2,4-二氯苯基）-3-氧代丙腈，AAA+ ATPase运动细胞质动力蛋白抑制剂
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关于此项目
经验公式（希尔记法）:
C17H8Cl3N3O2
化学文摘社编号:
分子量:
392.62
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
细胞质动力蛋白抑制剂，Ciliobrevin D, Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (~10 to 40 µM).
InChI key
JKKSCGHDRHRWOQ-FOWTUZBSSA-N
SMILES string
O=C(C1=CC=C(Cl)C=C1N/2)NC2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)/C#N
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange
solubility
DMSO: 2.5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Disclaimer
毒性：标准处理（A）
General description
一种可渗透细胞的苯甲酰二氢喹唑啉酮衍生物，可作为AAA+ATPase运动细胞质动力蛋白的可逆和特异性阻滞剂，并以剂量依赖的方式破坏主轴极聚焦，冷稳定的微管形成，动粒微管附着和黑素体聚集（约10至40 µM）。 显示会干扰原纤毛内的蛋白运输，并导致原纤毛远端的鞭毛内运输蛋白88（IFT88）水平显著增加。据报道破坏了原纤毛依赖性Gli调节并阻断了刺猬信号传导。
Other Notes
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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