质量水平
检测方案
≥97% dry basis
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to off-white
溶解性
DMSO: 25 mg/mL
chloroform: soluble
ethanol: soluble
methanol: soluble
运输
ambient
储存温度
2-8°C
InChI
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+
InChI key
PMATZTZNYRCHOR-IMVLJIQESA-N
一般描述
具有免疫抑制属性的环状寡肽。诱导大鼠胸腺细胞和鼠B细胞淋巴瘤细胞系WEHI-231的凋亡。但是，它可以在BLB细胞系中阻止抗-IgM和离子霉素诱导的细胞凋亡。环孢菌素A与亲环蛋白的复合物可以纳摩尔的亲和力对蛋白磷酸酶2B进行抑制。抑制由白介素-1α、脂多糖和TNF-α诱导的一氧化氮合成。从胚胎干细胞诱导形成心肌细胞。
材料是具有免疫抑制活性的一种非极性环状寡肽。似乎是通过与细胞内蛋白亲环蛋白相互作用而起作用的。亲环蛋白-环孢菌素A复合物是钙调神经磷酸酶（蛋白磷酸酶2B，PP2B）蛋白磷酸酶活性的一种有效抑制剂。诱导大鼠胸腺细胞和鼠B细胞淋巴瘤细胞系WEHI-231的凋亡；但是，它可以在BLB细胞系中阻止抗-IgM和离子霉素诱导的细胞凋亡。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。从胚胎干细胞诱导形成心肌细胞。
生化/生理作用
产物不与ATP竞争。
可逆：否
细胞渗透性：否
首要靶标
由白介素-1-诱导的NOSα
由白介素-1-诱导的NOSα
警告
毒性：致癌/致畸（D）
重悬
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。
其他说明
Yan, P., et al. 2008.Biochem.Biophys.Res. Commun.in press.
Hattori, Y., and Naranishi, N. 1995.Cell Immunol.165, 7.
Marumo, T., et al. 1995.Hypertension25, 764.
Crabtree, G.R., and Clipstone, N.A.1994.Annu.Rev. Biochem.63, 1045.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Montague, J.W., et al. 1994.J. Biol. Chem.269, 18877.
Fast, D.J., et al. 1993.J.Interferon Res. 13, 235.
Liu, J. 1993.Trends Pharmacol.Sci. 14, 182.
Fruman, D.A., et al. 1992.Proc.Natl.Acad.Sci. USA89, 3686.
Hattori, Y., and Naranishi, N. 1995.Cell Immunol.165, 7.
Marumo, T., et al. 1995.Hypertension25, 764.
Crabtree, G.R., and Clipstone, N.A.1994.Annu.Rev. Biochem.63, 1045.
Gottschalk, A.R., et al. 1994.Proc.Natl.Acad.Sci. USA91, 7350.
Montague, J.W., et al. 1994.J. Biol. Chem.269, 18877.
Fast, D.J., et al. 1993.J.Interferon Res. 13, 235.
Liu, J. 1993.Trends Pharmacol.Sci. 14, 182.
Fruman, D.A., et al. 1992.Proc.Natl.Acad.Sci. USA89, 3686.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
WGK
WGK 3
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In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the development of αβ thymocytes remains mostly unaffected.
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The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules. Here, we examined the relationship between neuronal depolarization activity and tau protein phosphorylation by employing
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