239824
CXCR7 Agonist, VUF11207
The CXCR7 Agonist, VUF11207 controls the biological activity of CXCR7. This small molecule/inhibitor is primarily used for Biochemicals applications.
别名:
CXCR7 Agonist, VUF11207, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist
登录查看公司和协议定价
所有图片(2)
About This Item
推荐产品
质量水平
方案
≥99% (HPLC)
表单
oil
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light yellow
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
O=C(N(CCC1N(C)CCC1)C/C(C)=C/C2=C(F)C=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3
InChI
1S/C27H35FN2O4/c1-19(15-20-9-6-7-11-23(20)28)18-30(14-12-22-10-8-13-29(22)2)27(31)21-16-24(32-3)26(34-5)25(17-21)33-4/h6-7,9,11,15-17,22H,8,10,12-14,18H2,1-5H3/b19-15+
InChI key
JVRRRKAXHMGUHZ-XDJHFCHBSA-N
一般描述
A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
生化/生理作用
Cell permeable: yes
Primary Target
CXCR7
CXCR7
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Wijtmans, M., et al. 2011, Eur J Med Chem51, 184.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门