239824
CXCR7 Agonist, VUF11207
The CXCR7 Agonist, VUF11207 controls the biological activity of CXCR7. This small molecule/inhibitor is primarily used for Biochemicals applications.
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别名:
CXCR7 Agonist, VUF11207, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist, RDC-1 Agonist, GPR159 Agonist
经验公式（希尔记法）:
C27H35FN2O4
推荐产品
质量水平
检测方案
≥99% (HPLC)
形式
oil
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light yellow
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
−20°C
SMILES字符串
O=C(N(CCC1N(C)CCC1)C/C(C)=C/C2=C(F)C=CC=C2)C3=CC(OC)=C(OC)C(OC)=C3
一般描述
A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
生化/生理作用
Cell permeable: yes
Primary Target
CXCR7
CXCR7
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Wijtmans, M., et al. 2011, Eur J Med Chem51, 184.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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