质量水平
检测方案
≥98% (HPLC)
形式
solid
效能
3.4 μM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
chloroform: soluble
ethanol: soluble
methanol: soluble
运输
ambient
储存温度
10-30°C
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
一般描述
一种抗真菌抗生素，在100 µg/ml时对几种病原菌没有抑制作用。抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。直接与易位酶相互作用，干扰易位步骤。抑制真核生物中无细胞蛋白的合成。竞争性抑制hFkBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt′s淋巴瘤细胞和包括啮齿动物巨噬细胞在内的多种其他细胞类型中引发凋亡。抑制用毒胡萝卜素，甲基泼尼松龙和离子霉素处理的大鼠胸腺细胞中的DNA裂解。在碱性溶液中迅速被破坏。
生化/生理作用
主要靶标
hFKBP12
hFKBP12
警告
毒性：高毒性 & 致癌性/致畸性（I）
重悬
复溶后，等分并冷冻长期保存（-20°C），或冷藏（4°C）短期保存。储备液可在4°C，pH 3-5下稳定保存6周。
其他说明
Christner, C., et al. 1999.J. Med. Chem. 42, 3615.
Lu, Q., et al. 1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Cotter, T.G., et al. 1992.Anticancer Res.12, 773.
Takano, Y.S., et al. 1991.J. Pathol.163, 329.
Waring, P. 1990.J. Biol. Chem. 265, 14476.
Lu, Q., et al. 1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Cotter, T.G., et al. 1992.Anticancer Res.12, 773.
Takano, Y.S., et al. 1991.J. Pathol.163, 329.
Waring, P. 1990.J. Biol. Chem. 265, 14476.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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