质量水平
检测方案
≥90% (by assay)
形式
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to brown
储存温度
room temp
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
一般描述
一种抗真菌抗生素，可抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。直接与易位酶相互作用，干扰易位步骤。抑制真核生物中无细胞蛋白的合成。 竞争性抑制hFKBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt′s淋巴瘤细胞和包括啮齿动物巨噬细胞在内的多种其他细胞类型中引发凋亡。诱导巨噬细胞中的DNA片段化，但抑制用毒胡萝卜素，甲基泼尼松龙和离子霉素处理的大鼠胸腺细胞中的DNA裂解。在碱性溶液中迅速被破坏。
一种抗真菌抗生素，可抑制真核生物中的蛋白质合成，但不抑制原核生物中的蛋白质合成。竞争性抑制hFKBP12（Ki = 3.4 µM）。在HL-60细胞、T细胞杂交瘤、Burkitt’s淋巴瘤细胞和其他细胞类型中引发凋亡。也可获得100 mg/mL环己酰亚胺（目录编号239765）的DMSO溶液（无菌过滤）。
警告
毒性：高毒性 & 致癌性/致畸性（I）
其他说明
Christner, C., et al. 1999.J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L.1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Waring, P. 1990.J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971.J. Biol. Chem.246, 174.
Pestka, S. 1971.Annu.Rev. Microbiol.25, 487.
Lu, Q. and Mellgreen,R.L.1996.Arch.Biochem.Biophys.334, 175.
Chow, S.C., et al. 1995.Exp.Cell Res.216, 149.
Waring, P. 1990.J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971.J. Biol. Chem.246, 174.
Pestka, S. 1971.Annu.Rev. Microbiol.25, 487.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Ling Ding et al.
The Journal of clinical investigation, 133(1) (2023-01-04)
Understanding the regulatory mechanisms of PD-L1 expression in tumors provides key clues for improving immune checkpoint blockade efficacy or developing novel oncoimmunotherapy. Here, we showed that the FDA-approved sodium-glucose cotransporter-2 (SGLT2) inhibitor canagliflozin dramatically suppressed PD-L1 expression and enhanced T
Zhan Liu et al.
Cell death discovery, 10(1), 298-298 (2024-06-23)
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed regulation of LIMA1 remains unclear. Here
Wenxin Zhang et al.
Acta pharmaceutica Sinica. B, 13(6), 2585-2600 (2023-07-10)
Mevalonate metabolism plays an important role in regulating tumor growth and progression; however, its role in immune evasion and immune checkpoint modulation remains unclear. Here, we found that non-small cell lung cancer (NSCLC) patients with higher plasma mevalonate response better
Heidi M Blank et al.
EMBO reports, 24(9), e57372-e57372 (2023-07-27)
How cells coordinate their metabolism with division determines the rate of cell proliferation. Dynamic patterns of metabolite synthesis during the cell cycle are unexplored. We report the first isotope tracing analysis in synchronous, growing budding yeast cells. Synthesis of leucine
Yujie Zhao et al.
Cancers, 13(14) (2021-07-25)
Whilst researches elucidating a diversity of intracellular mechanisms, platinum-resistant epithelial ovarian cancer (EOC) remains a major challenge in the treatment of ovarian cancer. Here we report that Exo70, a key subunit of the exocyst complex, contributes to both innate and
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门