C-Reactive Protein, Human Ascites

M.W. 23,000 (monomer); 115,000 (pentamer).

Native C-reactive protein from human ascites. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.

Native C-reactive protein from human ascites. Major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca²⁺-dependent binding to a variety of substrates. Important in the diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. 21 kDa) aggregates as a cyclic pentamer.

Please refer to vial label for lot-specific concentration.

Toxicity: Standard Handling (A)

In 150 mM NaCl, 20 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 7.5.

Prepared from ascites that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Single band by SDS-PAGE

Christner, R.B., and Mortensen, R.F. 1994. J. Biol. Chem. 269, 9760.

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