236020
依托莫西
≥98% (HPLC), solid, CPT-1 inhibitor
别名:
依托莫西, R(+)-2-[6-(4-氯苯氧基）己基]-环氧乙烷-2-羧酸钠盐水合物
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关于此项目
经验公式（希尔记法）:
C15H18ClO4 · Na
化学文摘社编号:
分子量:
320.74
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
产品名称
依托莫西, A cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells.
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL (or water)
运输
wet ice
储存温度
2-8°C
SMILES字符串
[Na+].Clc1ccc(cc1)OCCCCCC[C@]2(OC2)C(=O)[O-]
InChI
1S/C15H19ClO4.Na/c16-12-5-7-13(8-6-12)19-10-4-2-1-3-9-15(11-20-15)14(17)18;/h5-8H,1-4,9-11H2,(H,17,18);/q;+1/p-1/t15-;/m1./s1
InChI key
RPACBEVZENYWOL-XFULWGLBSA-M
一般描述
Etomoxir (ETO), an irreversible inhibitor of carnitine palmitoyltransferase I (CPT1), primarily impacts fatty acid oxidation. It is an epoxide-based medium-chain fatty acid used to study the biological effects of mitochondrial fatty acid β-oxidation. ETO shifts energy metabolism from fatty acids to glucose oxidation. Its mechanism of action involves reducing the transport of non-esterified fatty acids (NEFA) into the mitochondrial matrix, which subsequently reduces the substrate available for β-oxidation.
应用
Etomoxir has been used in:
- the evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument
- cell stimulation experiments to study its effects on fatty acid oxidation in metabolic syndrome-associated synoviocytes
- Seahorse assays to assess fatty acid oxidation in cultured cells by inhibiting carnitine palmitoyltransferase I (CPT1)
其他说明
由于该运输中有害物质的性质，您的订单可能需要支付额外的运输费用。某些尺寸的产品可免除其他有害材料的运输费用。请与您当地的销售办事处联系，以获取有关这些费用的更多信息。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
毒性：有毒（F）
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Maria A Ahonen et al.
Molecular medicine (Cambridge, Mass.), 28(1), 68-68 (2022-06-18)
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STAR protocols, 3(2), 101392-101392 (2022-05-24)
Metabolic switches play a critical role in the pathophysiology of cardiac diseases, including heart failure. Here, we describe an assay for long-chain fatty acid oxidation in neonatal mouse cardiomyocytes by using a SeaHorse Flux Analyzer (Agilent). This protocol is a
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