236015
COX-2 Inhibitor V, FK3311
The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.
登录查看公司和协议定价
所有图片(1)
别名:
COX-2 Inhibitor V, FK3311, 4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
经验公式（希尔记法）:
C15H13F2NO4S
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
ethanol: 15 mg/mL
DMSO: 30 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3
InChI key
DIIYLGZNZGPXRR-UHFFFAOYSA-N
一般描述
A cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Otani, Y., et al. 2007. J. Invest. Surg.20, 175.
Sunose, Y., et al. 2001. Transplant Proc.33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res.44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull.41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull.40, 2399.
Sunose, Y., et al. 2001. Transplant Proc.33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res.44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull.41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull.40, 2399.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门