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Merck
CN
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文件

236011

Sigma-Aldrich

COX-2 Inhibitor I

The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

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别名:
COX-2 Inhibitor I, LM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
经验公式（希尔记法）:
C18H16ClNO4S
CAS号:
416901-58-1
分子量:
377.84
UNSPSC代码:
12352200

质量水平

100

检测方案

≥97% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

methanol: 1 mg/mL
DMSO: 100 mg/mL

运输

ambient

储存温度

−20°C

一般描述

A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50 = 650 nM) and in whole blood (IC50 = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC50 >10 µM) and in whole blood (IC50 >100 µM).
A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50 = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50 = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).

生化/生理作用

Cell permeable: yes
Primary Target
COX-2 from human monocytes
Product does not compete with ATP.
Reversible: no
Target IC50: 650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Palomer, A., et al. 2002. J. Med. Chem.45, 1402.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Cheol Ho Heo et al.
Journal of functional biomaterials, 14(4) (2023-04-27)
Cyclooxygenase-2 (COX-2) is a biomolecule known to be overexpressed in inflammation. Therefore, it has been considered a diagnostically useful marker in numerous studies. In this study, we attempted to assess the correlation between COX-2 expression and the severity of intervertebral

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