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235425

Caspase-3 Substrate II, Fluorogenic

Name: Caspase-3 Substrate II, Fluorogenic
Brand: MM

Fluorogenic caspase-3 substrate.

别名:

Caspase-3 Substrate II, Fluorogenic, Ac-DEVD-AMC

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About This Item

经验公式（希尔记法）:

C₃₀H₃₇N₅O₁₃

CAS号:

169332-61-0

分子量:

675.64

MDL编号:

MFCD00671411

UNSPSC代码:

12352200

NACRES:

NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 10 mM

荧光

λ_ex 365-380 nm
λ_em 430-460 nm

运输

ambient

储存温度

−20°C

InChI

1S/C30H37N5O13/c1-13(2)26(35-27(44)18(7-8-22(37)38)33-29(46)19(11-23(39)40)31-15(4)36)30(47)34-20(12-24(41)42)28(45)32-16-5-6-17-14(3)9-25(43)48-21(17)10-16/h5-6,9-10,13,18-20,26H,7-8,11-12H2,1-4H3,(H,31,36)(H,32,45)(H,33,46)(H,34,47)(H,35,44)(H,37,38)(H,39,40)(H,41,42)/t18-,19-,20-,26-/m0/s1

InChI key

ALZSTTDFHZHSCA-RNVDEAKXSA-N

一般描述

Fluorogenic CPP32/Apopain substrate. Cleavage of this substrate by CPP32/Apopain shows Michaelis-Menten kinetics (K_m = 9.7 ± 1.0 µM). Cleavage can be monitored by excitation at 380 nm and emission at 460 nm.

Fluorogenic caspase-3 substrate. Cleavage of this substrate by caspase-3 shows Michaelis-Menten kinetics (K_m = 9.7 ± 1.0 µM). Also a substrate for caspase-6, caspase-7, caspase-8, and caspase-10.

生化/生理作用

Cell permeable: no

Km = 9.7 ± 1.0 µM for cleavage of this substrate by caspase-3

Primary Target
Fluorogenic caspase-3 substrate

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Asp-Glu-Val-Asp-AMC

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Hermission, M., et al. 2000. Oncogene 19, 2338.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W., et al. 1995. Nature 376, 37.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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