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Merck
CN

235420

Caspase-3 Inhibitor I

≥90% (HPLC), solid

别名:

Caspase-3 Inhibitor I, CPP32/Apopain Inhibitor, Ac-DEVD-CHO

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关于此项目

经验公式（希尔记法）:
C20H30N4O11
化学文摘社编号:
169332-60-9
分子量:
502.47
MDL编号:
MFCD00671412
UNSPSC代码:
12352200
NACRES:
NA.77

主要文件

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产品名称

Caspase-3 Inhibitor I, The Caspase-3 Inhibitor I, also referenced under CAS 169332-60-9, controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

质量水平

100

方案

≥90% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

DMSO: 5 mg/mL
water: soluble

运输

ambient

储存温度

−20°C

SMILES字符串

N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O

InChI

1S/C20H30N4O11/c1-9(2)17(20(35)22-11(8-25)6-15(29)30)24-18(33)12(4-5-14(27)28)23-19(34)13(7-16(31)32)21-10(3)26/h8-9,11-13,17H,4-7H2,1-3H3,(H,21,26)(H,22,35)(H,23,34)(H,24,33)(H,27,28)(H,29,30)(H,31,32)/t11-,12-,13-,17-/m0/s1

InChI key

UMBVAPCONCILTL-MRHIQRDNSA-N

相关类别

一般描述

A specific and reversible inhibitor of CPP32/Apopain/Yama (IC50 = 0.2 nM). A member of the ICE/CED-3 family of cysteine proteases, which are important in apoptosis.
A very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.

生化/生理作用

Cell permeable: no
Primary Target
Capase-3, capase-6, capase-7, capase-8, capase-10
Product does not compete with ATP.
Reversible: yes
Target IC50: 200 pM against caspase-3

包装

Yes

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ac-Asp-Glu-Val-Asp-CHO
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Nicholson, D.W. 1996. Nature Biotech. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Nicholson, D.W., et al. 1995. Nature376, 37.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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