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Merck
CN

234610

Congo Red, High Purity

An amyloidophylic dye that specifically stains stacked β sheet aggregates.

别名:

Congo Red, High Purity, 3,3ʹ-[(1,1ʹ-Biphenyl)-4,4ʹ-diylbis(azo)]bis(4-amino-1-naphthalenesulfonic Acid) 2Na

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关于此项目

经验公式（希尔记法）:
C32H22N6O6S2 · 2Na
化学文摘社编号:
573-58-0
分子量:
696.66
UNSPSC Code:
12171500
NACRES:
NA.25
MDL number:
MFCD00004028

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产品名称

Congo Red, High Purity, An amyloidophylic dye that specifically stains stacked β sheet aggregates.

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])c1c2c(c(c(c1)N=Nc3ccc(cc3)c4ccc(cc4)N=Nc5c(c6c(c(c5)[S](=O)(=O)[O-])cccc6)N)N)cccc2

InChI

1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2

InChI key

IQFVPQOLBLOTPF-UHFFFAOYSA-L

description

Merck USA index - 14, 2498

assay

≥75% dye basis

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

rust

solubility

water: 10 mg/mL
ethanol: soluble

shipped in

ambient

storage temp.

15-25°C

Quality Level

100

Biochem/physiol Actions

Primary Target
An amyloidophylic dye that specifically stains stacked β sheet aggregates
Product does not compete with ATP.
Reversible: no
Cell permeable: no

Disclaimer

Toxicity: Standard Handling (A)

General description

An amyloidophylic dye that specifically stains stacked β sheet aggre-gates. Useful for staining and visual detection of amyloid deposits in nerve tissue. Binds to amyloid fibrils but not to non-polymerized amyloid peptide. Inhibits the accumulation of the scrapie-associated, protease-resistant isoform of protein PrP without affecting the normal isoform possibly through overstabilization of the conformation. It is also shown to inhibit Pot1 Binding to Telomeric DNA.

Other Notes

Altschuler, S.E., et al. 2012. Biochemistrin press.
Khurana, R., et al. 2001. J. Biol. Chem.276, 22715.
Fezoui, Y., et al. 2000. Amyloid7, 166.
Fezoui, Y., et al. 2000. Nat. Struct. Biol.7, 1095.
Kramport, M., et al. 2000. Chem. Biol.7, 855.
Kuner, P., et al. 2000. J. Biol. Chem.275, 1673.
Caspi, S., et al. 1998. J. Biol. Chem.273, 3484.
Caughey, B., and Race, A.E. 1992. J. Neurochem.59, 768.
Taylor, D.L., et al. 1974. J. Histochem. Cytochem.22, 1105.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at room temperature (20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 1B - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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