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234109-M

Colcemid

Name: Colcemid
Brand: MM

≥98% (HPLC), Microtuble polymeration inhibitor, crystalline powder

别名:

Colcemid, Demecolcine

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₅NO₅

化学文摘社编号:

477-30-5

分子量:

371.43

UNSPSC Code:

12352200

MDL number:

MFCD00075459

NACRES:

NA.25

Assay:

≥98% (HPLC)

Form:

crystalline powder

Quality level:

100

Storage condition:

OK to freeze

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属性

产品名称

Colcemid, Cell synchronization agent.

Quality Level

100

description

Merck USA index - 14, 2887

assay

≥98% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

chloroform: 10 mg/mL, ethanol: soluble

storage temp.

10-30°C

SMILES string

N(C1CCc2c(c(c(c(c2)OC)OC)OC)C3=CC=C(C(=O)C=C31)OC)C

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3

InChI key

NNJPGOLRFBJNIW-UHFFFAOYSA-N

说明

General description

Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.

Biochem/physiol Actions

Primary Target
Depolymerizes microtubules and limits microtubule formation.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

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pictograms

GHS06

signalword

Danger

hcodes

H300

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c