MDM2/CK1δ Protein, active, 10 µg

MDM2 is an E3 ubiquitin ligase that regulates the turnover of several cellular factors including the p53 tumour suppressor protein and notably MDM2 itself. The suppression of p53 activity by an amplified Mdm2 gene has been observed in many tumours, including soft tissue sarcomas, osteosarcomas and breast tumours.

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli.

Ubiquitination Cascade Comoponent: E3

Purified using glutathione sepharose followed by gel filtration.

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

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