推荐产品
产品名称
CCR2拮抗剂, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
质量水平
方案
≥97% (racemic mixture, HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
protect from light
颜色
white
溶解性
ethanol: 6 mg/mL
DMSO: 60 mg/mL
运输
ambient
储存温度
2-8°C
一般描述
一种顺式二氨基环己基脲化合物，可有效竞争MCP-1与CCR2的结合（IC50=5.1 nM），并有效抑制MCP-1/CCR2介导的PBMC Ca+2通量和趋化性（IC50分别为18和1 nM），而对嗜酸性粒细胞趋化因子与CCR3结合的作用要小得多（在10 µM时抑制37%）。诱变分析表明CCR2 Thr292在维持高亲和力拮抗剂结合中至关重要。
包装
用惰性气体包装
警告
毒性：标准处理（A）
制备说明
完全溶解可能需要温和加热，快速搅拌和/或超声处理。
重悬
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。
其他说明
Cherney, R.J., et al. 2008.J. Med. Chem.51, 721.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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