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Merck
CN

220551

氯霉素，大包装

Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

别名:

氯霉素，大包装

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关于此项目

经验公式（希尔记法）:
C11H12Cl2N2O5
化学文摘社编号:
56-75-7
分子量:
323.13
UNSPSC Code:
12352200
MDL number:
MFCD00078159

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产品名称

氯霉素，大包装, Chloramphenicol, CAS 56-75-7, is a synthetic bacteriostatic antibiotic that inhibits the translation of RNA by blocking the peptidyltransferase reaction on ribosomes.

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)

InChI key

WIIZWVCIJKGZOK-UHFFFAOYSA-N

assay

≥97% (by Assay)

form

crystalline powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

gray to off-white

solubility

water: 2.5 mg/mL
methanol: 35 mg/mL
ethanol: soluble

shipped in

ambient

storage temp.

10-30°C

Quality Level

100

相关类别

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

功效：≥970 µg/mg
首要靶标
RNA的翻译

General description

通过与50S核糖体亚基结合来抑制RNA到蛋白质的翻译，从而阻止肽基转移酶反应的合成抑菌抗生素。氯霉素抗性由抗性基因cat编码，其产物氯霉素乙酰转移酶可通过乙酰化使抗生素失活。通常以30-50 µg/ml用于筛选带有氯霉素抗性的大肠杆菌。

Other Notes

Lech, K., and Brent, R. 1995. in Current Protocols in Mol.Biol. Vol. 1, (Ausubel, F.M., et al., Eds.)John Wiley & Sons, New York.
Lu, J., and Jiang, C. 1993.Biochem.Biophys.Res. Commun.196, 12.
Saltarelli, M.J., et al. 1993.Virol.197, 35.
Holt, J.T. 1992.Ann.N.Y.Acad.Sci.660, 88.
Maniatis, T., et al. 1989.In Molecular Cloning, A Laboratory Manual, Second Edition.Cold Spring Harbor, NY, p. 1.6, A.6.

pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

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