219433
Cathepsin L Inhibitor IV
The Cathepsin L Inhibitor IV controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
别名:
Cathepsin L Inhibitor IV, 1-Naphthalenesulfonyl-IW-CHO
登录查看公司和协议定价
所有图片(1)
About This Item
经验公式（希尔记法）:
C27H29N3O4S
分子量:
491.60
UNSPSC代码:
12352200
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white to off-white
溶解性
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Also inhibits the release of Ca2+ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC50 = 1.9 nM). Inhibits the release of Ca2+ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
生化/生理作用
Cell permeable: yes
Primary Target
cathepsin L
cathepsin L
Product does not compete with ATP.
Reversible: yes
Target IC50: 1.9 nM against Cathepsin L
警告
Toxicity: Standard Handling (A)
序列
1-Naphthalenesulfonyl-Ile-Trp-CHO
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Saara Hämälistö et al.
Nature communications, 11(1), 229-229 (2020-01-15)
Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular space and cell death when released to the cytosol. Here
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门