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安全信息

219402

Sigma-Aldrich

Cathepsin L, Human Liver

Cathepsin L, Human Liver, CAS 60616-82-2, is a native, the most potent of all the lysosomal proteinases. Plays a major role in the proteolysis of both cellular and endocytosed macromolecules.

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EC 号:
3.4.22.15 (BRENDA, IUBMB)
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

100

形式

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles

运输

wet ice

储存温度

−70°C

一般描述

Cathepsin L, Human Liver, CAS 60616-82-2, is a native, the most potent of all the lysosomal proteinases. Plays a major role in the proteolysis of both cellular and endocytosed macromolecules.
Native cathepsin L from human liver. The most potent of the lysosomal proteinases, having a higher activity than cathepsins B and H in the degradation of a variety of physiological protein substrates. Cathepsin L is believed to be responsible for the generation of endostatin from NC1 domain in collagen XVII.
Native cathepsin L from human liver. The most powerful of the lysosomal proteinases, having a higher specific activity than cathepsins B and H in the degradation of a variety of physiological protein substances.
Note: 1 mU = 1 milliunit.

包装

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

单位定义

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Z-FR-AFC per min at 25°C, pH 5.5.

外形

In 400 mM NaCl, 20 mM malonate buffer, 1 mM EDTA, pH 5.5.

制备说明

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

重悬

Following initial thaw, aliquot and freeze (-70°C).

其他说明

Kurata, M., et al. 2001. J. Biochem. (Tokyo)130, 857.
Ferreras, M., et al. 2000. FEBS Lett.486, 247.
Baricos, W.H., et al. 1988. Biochem. J.252, 301.
McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun.151, 827.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

法规信息

高风险级别生物产品--人源产品

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Cathepsin L
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, 121-133 (2015)
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Mutations in the human serine protease 1 gene (PRSS1), which encodes cationic trypsinogen, can accelerate its autoactivation and cause hereditary or sporadic chronic pancreatitis. Disruption of the locus that encodes cationic trypsinogen in mice (T7) causes loss of expression of

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