推荐产品
生物来源
rabbit
质量水平
抗体形式
saturated ammonium sulfate (SAS) precipitated
抗体产品类型
primary antibodies
克隆
polyclonal
表单
liquid
包含
≤0.1% sodium azide as preservative
种属反应性
human
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
同位素/亚型
IgG
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
一般描述
Anti-Cathepsin D, rabbit polyclonal, recognizes the ~50 kDa latent and the ~30 kDa active forms in breast carcinoma cell line. It is validated for ELISA, Western blotting, and immunoelectrophoresis.
Rabbit polyclonal antibody purified by ammonium sulfate precipitation. Recognizes the ~50 kDa latent and the ~30 kDa active forms of cathepsin D.
Recognizes the ~50 kDa latent and the ~30 kDa active forms of cathepsin D in breast carcinoma cell line.
免疫原
Human
purified human liver cathepsin D
应用
ELISA (≥1:1000)
Immunoelectrophoresis (see comments)
Immunoelectrophoresis (see comments)
包装
Please refer to vial label for lot-specific concentration.
警告
Toxicity: Standard Handling (A)
外形
In PBS.
重悬
Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
分析说明
Positive Control
Human liver tissue
Human liver tissue
其他说明
Monospecific for cathepsin D as determined by a single arc by immunoelectrophoresis against crude live extract and purified cathepsin D. Variables associated with assay conditions will dictate the proper working dilution.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
M Heinrich et al.
Cell death and differentiation, 11(5), 550-563 (2004-01-24)
Acidic noncaspase proteases-like cathepsins have been introduced as novel mediators of apoptosis. A clear role for these proteases and the acidic endolysosomal compartment in apoptotic signalling is not yet defined. To understand the role and significance of noncaspases in promoting
Loss of the Batten disease gene CLN3 prevents exit from the TGN of the mannose 6-phosphate receptor.
Daniel J Metcalf et al.
Traffic (Copenhagen, Denmark), 9(11), 1905-1914 (2008-09-27)
The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are a group of inherited childhood-onset neurodegenerative disorders characterized by the lysosomal accumulation of undigested material within cells. To understand this dysfunction, we analysed trafficking of the cation-independent mannose 6-phosphate receptor (CI-MPR), which
Maya M Polovitskaya et al.
American journal of human genetics, 107(6), 1062-1077 (2020-11-21)
Dysfunction of the endolysosomal system is often associated with neurodegenerative disease because postmitotic neurons are particularly reliant on the elimination of intracellular aggregates. Adequate function of endosomes and lysosomes requires finely tuned luminal ion homeostasis and transmembrane ion fluxes. Endolysosomal
Rachel Allison et al.
The Journal of cell biology, 216(5), 1337-1355 (2017-04-09)
Contacts between endosomes and the endoplasmic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved and consequences of tubule fission failure are incompletely understood. We found that interaction between the microtubule-severing enzyme spastin and the ESCRT protein IST1 at
Gonzalo A Mardones et al.
Molecular biology of the cell, 18(9), 3486-3501 (2007-06-29)
The sorting of acid hydrolase precursors at the trans-Golgi network (TGN) is mediated by binding to mannose 6-phosphate receptors (MPRs) and subsequent capture of the hydrolase-MPR complexes into clathrin-coated vesicles or transport carriers (TCs) destined for delivery to endosomes. This
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