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质量水平
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
water: 1 mg/mL
DMSO: 5 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
A tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).
Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).
生化/生理作用
Cell permeable: no
Primary Target
caspase-3, caspase-7
caspase-3, caspase-7
Product does not compete with ATP.
Reversible: yes
Target IC50: 3.2 nM and 22.6 nM, against caspases-3 and -7, respectively
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
Ac-Asp-Asn-Leu-Asp-CHO
分析说明
Single main spot with additional trace spot by TLC
其他说明
Yoshimori, A., et al. 2004. BMC Pharmacol.4, 7.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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