推荐产品
产品名称
半胱氨酸蛋白酶-8抑制物II, The Caspase-8 Inhibitor II controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
质量水平
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated
颜色
white to yellow
溶解性
DMSO: 10 mM
运输
ambient
储存温度
−20°C
一般描述
一种有效、细胞可渗透性且不可逆的caspase-8和颗粒酶B的抑制剂。有效抑制流行性感冒病毒诱导的HeLa细胞凋亡。还抑制颗粒酶B。当与纯化的天然或重组酶一起使用时，需要用酯酶进行预处理。也可使用5 mM（250 µg/76 µl）Z-IETD-FMK（目录号218840）的DMSO溶液。
一种有效、细胞可渗透性且不可逆的caspase-8（MACH，FLICE，Mch5）抑制剂。也抑制颗粒酶B。
生化/生理作用
主要靶标
caspase-8
caspase-8
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
警告
毒性：标准处理（A）
序列
Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F*
重悬
复溶后，等分并冷冻（-20°C）。储备溶液在-20°C下可稳定保存8个月。
分析说明
≥98%（HPLC）
其他说明
Takizawa, T., et al. 1999.Microbiol.Immunol.43, 245.
Martin, D.A., et al. 1998.J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281, 1312.
Martin, D.A., et al. 1998.J. Biol. Chem.273, 4345.
Sweeney, E.A., et al. 1998.FEBS Lett.425, 61.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281, 1312.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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