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经验公式(希尔记法):
C22H36N4O9
化学文摘社编号:
分子量:
500.54
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.54
产品名称
Caspase-4 Inhibitor I, The Caspase-4 Inhibitor I, also referenced under CAS 402832-01-3, controls the biological activity of Caspase-4. This small molecule/inhibitor is primarily used for Cancer applications.
InChI key
MXGJLIBJKIIQSF-FPXQBCRKSA-N
InChI
1S/C22H36N4O9/c1-11(2)8-16(23-13(5)28)21(34)25-15(6-7-17(29)30)20(33)26-19(12(3)4)22(35)24-14(10-27)9-18(31)32/h10-12,14-16,19H,6-9H2,1-5H3,(H,23,28)(H,24,35)(H,25,34)(H,26,33)(H,29,30)(H,31,32)/t14-,15-,16-,19-/m0/s1
SMILES string
N([C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CCC(=O)O
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
caspase-4
caspase-4
Product does not compete with ATP.
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A reversible caspase-4 (ICH-2) inhibitor.
A reversible caspase-4 inhibitor.
Other Notes
Ac-Leu-Glu-Val-Asp-CHO
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Zahara L Chaudhry et al.
Brain sciences, 12(4) (2022-04-22)
The outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) signifies a serious worldwide concern to public health. Both transcriptome and proteome of SARS-CoV-2-infected cells synergize the progression of infection in host, which may exacerbate symptoms and/or
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