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Merck
CN
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文件

218728

Sigma-Aldrich

Caspase-9 Inhibitor III

The Caspase-9 Inhibitor III, also referenced under CAS 403848-57-7, controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

Caspase-9 Inhibitor III, Ac-LEHD-CMK

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About This Item

经验公式（希尔记法）:
C24H35ClN6O9
CAS号:
403848-57-7
分子量:
587.02
UNSPSC代码:
12352200
NACRES:
NA.54

质量水平

100

检测方案

≥95% (HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated

颜色

white

溶解性

water: 1 mg/mL
DMSO: 5 mg/mL

运输

ambient

储存温度

−20°C

一般描述

A potent and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6). Reported to reduce myocardial infarct size during reperfusion (~70 nM).
A potent, irreversible inhibitor of caspase-9. Reported to reduce myocardial infarct size during reperfusion (~70 nM).

生化/生理作用

Cell permeable: yes
Primary Target
caspase-9
Product does not compete with ATP.
Reversible: no
Target IC50: 70 nM against caspase-9

警告

Toxicity: Standard Handling (A)

序列

Ac-Leu-Glu-His-Asp-CMK

其他说明

Mocanu, M.M., et al. 2000. Br. J. Pharmacol.130, 197.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Hazel Stewart et al.
iScience, 26(11), 108080-108080 (2023-10-20)
The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has been confirmed independently by ribosome profiling.

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