5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺

Name: 5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺
Brand: MM

The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺, 5-氨基-3-（（4-(磺酰胺)苯基）氨基）-N-（2,6-二氟苯基）-1H-1,2,4-三唑-1-硫代酰胺

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关于此项目

经验公式（希尔记法）:

C₁₅H₁₃F₂N₇O₂S₂

化学文摘社编号:

443798-55-8

分子量:

425.44

MDL number:

MFCD09264159

UNSPSC Code:

12352200

NACRES:

NA.77

主要文件

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产品名称

5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺, The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SMILES string

Fc1c(c(ccc1)F)NC(=S)[n]2nc(nc2N)Nc3ccc(cc3)[S](=O)(=O)N

InChI

1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)

InChI key

ARIOBGGRZJITQX-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 10 mg/mL
THF: soluble
acetone: soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Packaging

用惰性气体包装

Biochem/physiol Actions

主要靶标
Cdk1/细胞周期蛋白B，Cdk2/细胞周期蛋白A

产物与ATP竞争。

可逆性：是

细胞可渗透性：是

靶标IC₅₀：对于HCT-116，HeLa和A375细胞的抗增殖特性，分别为20 nM，35 nM和92 nM；针对Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A，分别为600 pM和500 pM

Disclaimer

毒性：有害（C）

General description

一种可渗透细胞的三唑并二胺化合物，在各种人类癌细胞中均具有抗增殖特性（HCT-116，HeLa和A375细胞的IC₅₀分别为20 nM，35 nM和92 nM）。作为Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A（IC₅₀分别为600 pM和500 pM）的高效，可逆，ATP竞争性抑制剂，对VEGF-R2（IC₅₀=32 nM），GSK-3β（IC₅₀=140 nM）和一组其他八种激酶（IC₅₀ ≥ 1 µM）具有选择性。

Other Notes

Lin, R., et al. 2005.J.Med. Chem.48, 4208.

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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The rates of adult neurogenesis and oligodendrogenesis are linked to cell cycle regulation through p27-dependent gene repression of SOX2.

Ana Domingo-Muelas et al.

Cellular and molecular life sciences : CMLS, 80(1), 36-36 (2023-01-11)

Cell differentiation involves profound changes in global gene expression that often has to occur in coordination with cell cycle exit. Because cyclin-dependent kinase inhibitor p27 reportedly regulates proliferation of neural progenitor cells in the subependymal neurogenic niche of the adult mouse

CDK4/6 initiates Rb inactivation and CDK2 activity coordinates cell-cycle commitment and G1/S transition.

Sungsoo Kim et al.

Scientific reports, 12(1), 16810-16810 (2022-10-08)

External signaling controls cell-cycle entry until cells irreversibly commit to the cell cycle to ensure faithful DNA replication. This process is tightly regulated by cyclin-dependent kinases (CDKs) and the retinoblastoma protein (Rb). Here, using live-cell sensors for CDK4/6 and CDK2

Molecular control of cell density-mediated exit to quiescence.

Yilin Fan et al.

Cell reports, 36(4), 109436-109436 (2021-07-29)

Contact inhibition of cell proliferation regulates tissue size and prevents uncontrolled cell expansion. When cell density increases, contact inhibition can force proliferating cells into quiescence. Here we show that the variable memory of local cell density experienced by a mother

Cell cycle inertia underlies a bifurcation in cell fates after DNA damage.

Jenny F Nathans et al.

Science advances, 7(3) (2021-02-02)

The G1-S checkpoint is thought to prevent cells with damaged DNA from entering S phase and replicating their DNA and efficiently arrests cells at the G1-S transition. Here, using time-lapse imaging and single-cell tracking, we instead find that DNA damage

Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.

Antonio P A Ferreira et al.

Nature communications, 12(1), 2424-2424 (2021-04-25)

Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Fast Endophilin-mediated endocytosis, FEME, is not constitutively active but triggered upon receptor activation. High levels of growth factors induce spontaneous FEME, which can be suppressed upon serum starvation. This

5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺

The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

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主要文件

属性

产品名称

SMILES string

InChI

InChI key

assay

form

manufacturer/tradename

storage condition

color

solubility

shipped in

storage temp.

Quality Level

相关类别

说明

Preparation Note

Legal Information

Packaging

Biochem/physiol Actions

Disclaimer

General description

Other Notes

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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