217714
5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺
The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
5-氨基-3-（（4 -（氨基磺酰基）苯基）氨基）-N-（2，6-二氟苯基）-1H-1,2，4-三唑-1-硫代乙酰胺, 5-氨基-3-（（4-(磺酰胺)苯基）氨基）-N-（2,6-二氟苯基）-1H-1,2,4-三唑-1-硫代酰胺
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所有图片(1)
About This Item
推荐产品
质量水平
方案
≥95% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 10 mg/mL
THF: soluble
acetone: soluble
运输
ambient
储存温度
2-8°C
SMILES字符串
Fc1c(c(ccc1)F)NC(=S)[n]2nc(nc2N)Nc3ccc(cc3)[S](=O)(=O)N
InChI
1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
InChI key
ARIOBGGRZJITQX-UHFFFAOYSA-N
一般描述
一种可渗透细胞的三唑并二胺化合物，在各种人类癌细胞中均具有抗增殖特性（HCT-116，HeLa和A375细胞的IC50分别为20 nM，35 nM和92 nM）。作为Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A（IC50分别为600 pM和500 pM）的高效，可逆，ATP竞争性抑制剂，对VEGF-R2（IC50=32 nM），GSK-3β（IC50=140 nM）和一组其他八种激酶（IC50 ≥ 1 µM）具有选择性。
生化/生理作用
主要靶标
Cdk1/细胞周期蛋白B，Cdk2/细胞周期蛋白A
Cdk1/细胞周期蛋白B，Cdk2/细胞周期蛋白A
产物与ATP竞争。
可逆性：是
细胞可渗透性：是
靶标IC50：对于HCT-116，HeLa和A375细胞的抗增殖特性，分别为20 nM，35 nM和92 nM；针对Cdk1/细胞周期蛋白B和Cdk2/细胞周期蛋白A，分别为600 pM和500 pM
包装
用惰性气体包装
警告
毒性：有害（C）
重悬
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
其他说明
Lin, R., et al. 2005.J.Med. Chem.48, 4208.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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