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Merck
CN

216100-M

Carboplatin

An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

别名:

Carboplatin, cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II), JM-8, Paraplatin

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关于此项目

经验公式（希尔记法）:
C6H12N2O4Pt
化学文摘社编号:
41575-94-4
分子量:
371.25
UNSPSC Code:
12352200
MDL number:
MFCD00070464
NACRES:
NA.77

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产品名称

Carboplatin, An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

SMILES string

[Pt]1OC(=O)C2(CCC2)C(=O)O1.[N+H4].[N+H4]

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-N

description

Merck USA index - 14, 1822

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water with 5% glucose: 10 mg/mL

storage temp.

10-30°C

Quality Level

100

Biochem/physiol Actions

Primary Target
Potent antitumor activity

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

General description

An analog of cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.



Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.
An analog of Cisplatin (Cat. No. 232120 ) with reduced nephrotoxicity. Displays potent antitumor activity.


Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.

Other Notes

Hall, M.D., et al. 2014. Cancer Res. In press.
Smith, I.E., et al. 1985. Cancer Treat. Rep. 69, 43.
Harland, S.J., et al. 1984. Cancer Res. 44, 1693.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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