215900
Carbonic Anhydrase IX/XII Inhibitor
The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Carbonic Anhydrase IX/XII Inhibitor, CAIX Inhibitor
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About This Item
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质量水平
方案
≥98% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
溶解性
DMSO: 50 mg/mL
运输
ambient
储存温度
2-8°C
SMILES字符串
O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(N(=O)=O)C=C2
一般描述
A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.
A cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.
包装
Packaged under inert gas
警告
Toxicity: Regulatory Review (Z)
其他说明
Pacchiano, F., et al. 2011. J Med Chem.54, 1896.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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