212385-M
Carbamoylcholine chloride
≥98% (titration), nicotinic and muscarinic receptor agonist, solid (fine crystalline)
别名:
Carbachol, Carbamoylcholine Chloride
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关于此项目
经验公式（希尔记法）:
C6H15ClN2O2
化学文摘社编号:
分子量:
182.65
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Carbachol, An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors.
SMILES string
Cl.[N+](CCO\C(=N\[H])\[O-])(C)(C)C
InChI
1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
InChI key
AIXAANGOTKPUOY-UHFFFAOYSA-N
description
Merck USA index - 14, 1779
assay
≥98% (titration)
form
solid (fine crystalline)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
color
white
solubility
methanol: 100 mg/mL
water: 100 mg/mL
ethanol: 20 mg/mL
storage temp.
10-30°C
Quality Level
Biochem/physiol Actions
Primary Target
Agonist for nicotinic and muscarinic acetylcholine receptors
Agonist for nicotinic and muscarinic acetylcholine receptors
Disclaimer
Toxicity: Highly Toxic (H)
General description
An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca2+ and InsP3 and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
Other Notes
Jence, M., et al. 1995. J. Neurochem. 64, 1605.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.
Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.
Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.
Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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