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COA分析证书/COQ

208902

Calpastatin Peptide

Name: Calpastatin Peptide
Brand: MM

A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC₅₀ = 20 nM for purified rabbit calpain II).

别名:

Calpastatin Peptide, CS Peptide

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About This Item

经验公式（希尔记法）:

C₁₄₂H₂₃₀N₃₆O₄₄S

分子量:

3177.63

UNSPSC代码:

12352202

NACRES:

NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

lyophilized solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

1% acetic acid: 1 mg/mL
water: 1 mg/mL

运输

ambient

储存温度

−20°C

一般描述

A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC₅₀ = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase C_ε (PKC_ε) in rat pituitary GH₄C₁ cells stimulated by thyrotropin-releasing hormone (TRH).

A 27-amino acid, peptide encoded by exon 1B of human calpastatin that acts as a cell-permeable and potent inhibitor of calpain I and calpain II (IC₅₀ = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase C_ε (PKC_ε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).

生化/生理作用

Cell permeable: yes

Primary Target
calpain 2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 20 nM against calpain II

警告

Toxicity: Standard Handling (A)

序列

Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Eto, A., et al. 1995. J. Biol. Chem. 270, 25115.
Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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