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Merck
CN
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文件

208735

Sigma-Aldrich

Calmodulin Inhibitory Peptide

The Calmodulin Inhibitory Peptide controls the biological activity of Calmodulin. This small molecule/inhibitor is primarily used for Cell Signaling applications.

别名:

Calmodulin Inhibitory Peptide, MLCK Peptide, MLCKP

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About This Item

经验公式(希尔记法):
C91H156N36O20
分子量:
2074.44
UNSPSC代码:
12352202
NACRES:
NA.77

质量水平

检测方案

≥95% (HPLC)

形式

lyophilized

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

溶解性

water: 50 mg/mL

运输

ambient

储存温度

−20°C

一般描述

A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (Kd = 6 pM).
A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (Kd = 6 pM). Inhibits calmodulin activation of MLCK-catalyzed phosphorylation of smooth muscle regulatory light chain(MLC).

生化/生理作用

Cell permeable: no
Kd = 6 pM in binding to calmodulin
Primary Target
Calmodulin
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-NH₂

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Torok,K., et al. 1998. Biochemistry 37, 6188.
Török, K., and Trentham, D.R. 1994. Biochemistry33, 12807.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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