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208724

Sigma-Aldrich

钙蛋白酶抑制剂IV

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

钙蛋白酶抑制剂IV, Z-LLY-FMK

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About This Item

经验公式（希尔记法）:
C30H40FN3O6
分子量:
557.65
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated

颜色

white to pale yellow

溶解性

DMSO: 25 mg/mL

运输

ambient

储存温度

−20°C

一般描述

一种有效的，细胞可渗透且不可逆的钙蛋白酶II抑制剂（k2 = 28,900 M-1s-1）。还用作组织蛋白酶L的抑制剂（k2 = 680,000 M-1s-1）。

生化/生理作用

主要靶标
钙蛋白酶2
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
钙蛋白酶II的抑制中，k₂ = 28,900 M⁻¹s⁻¹ ；组织蛋白酶L的抑制中，k2 = 680,000 M⁻¹s⁻¹

警告

毒性：标准处理（A）

序列

Z-Leu-Leu-Tyr-CH₂F

重悬

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。

分析说明

TLC测定单个斑点

其他说明

Dutt, P., et al. 1998.FEBS Lett.436, 367.
Angliker, H., et al. 1992.J. Med. Chem. 35, 216.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Kirill Gorshkov et al.
ACS infectious diseases, 7(6), 1389-1408 (2020-12-22)
Understanding the SARS-CoV-2 virus' pathways of infection, virus-host-protein interactions, and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and design of new therapeutics to treat COVID-19. Chloroquine and hydroxychloroquine, extensively explored as clinical agents for COVID-19, have
Anna Luganini et al.
mBio, 14(4), e0074923-e0074923 (2023-07-21)
The human cytomegalovirus (HCMV) US12 gene family contributes to virus-host interactions by regulating the virus' cell tropism and its evasion of host innate immune responses. US21, one of the 10 US12 genes (US12-US21), is a descendant of a captured cellular
Vimala Bondada et al.
Biochimica et biophysica acta. Molecular cell research, 1868(7), 119019-119019 (2021-04-04)
The enzymatic characteristics of the ubiquitous calpain 5 (CAPN5) remain undescribed despite its high expression in the central nervous system and links to eye development and disease. CAPN5 contains the typical protease core domains but lacks the C terminal penta-EF

相关内容

Protease Inhibitor Selection: Avoid Protein Loss in Sample Prep

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