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208721

ALLM

Name: ALLM
Brand: MM

Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 600 pM).

别名:

ALLM, Calpain Inhibitor II

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About This Item

经验公式（希尔记法）:

C₁₉H₃₅N₃O₄S

CAS号:

110115-07-6

分子量:

401.56

MDL编号:

MFCD00065506

UNSPSC代码:

12352200

NACRES:

NA.77

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钙蛋白酶抑制剂 II

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抗磷酸化组蛋白 H3 (pSer ¹⁰) 兔抗

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钙蛋白酶抑制剂 III

质量水平

100

方案

>95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze

颜色

off-white

溶解性

DMSO: 5 mg/mL
ethanol: 5 mg/mL
methanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O)C

InChI

1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1

InChI key

RJWLAIMXRBDUMH-ULQDDVLXSA-N

一般描述

A cell-permeable inhibitor of calpain I (K_i = 120 nM), calpain II (K_i = 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Cell permeable inhibitor of calpain I (K_i= 120 nM), calpain II (K_i= 230 nM), cathepsin B (K_i = 100 nM), and cathepsin L (K_i = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV⁺ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.

生化/生理作用

Cell permeable: yes

Primary Target
calpain-1

Product does not compete with ATP.

Reversible: no

Target K_i: 120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively

警告

Toxicity: Standard Handling (A)

序列

N-Acetyl-Leu-Leu-Met

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ravid, T., et al. 2000. J. Biol. Chem.275, 35840.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Sarin, A., et al. 1994. J. Immunol.153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Banik, N.L., et al. 1992. Neurochem. Res.17, 797.
Koohmaraie, M. 1992. Biochemie74, 239.
Pinter, M., et al. 1992. Biochemistry31, 8201.
Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol.138, 24.
Sasaki, T., et al. 1990. J. Enzyme Inhib.3, 195.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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主要文件

ALLM