208711
Ca2+/Calmodulin Kinase II Inhibitor 281-309
The Ca2+/Calmodulin Kinase II Inhibitor 281-309 controls the biological activity of Ca2+/Calmodulin Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Ca2+/Calmodulin Kinase II Inhibitor 281-309, CaM Kinase II Inhibitor 281-309, MHRQETVDCLKKFNARRKLKGAILTTMLA-OH
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About This Item
推荐产品
质量水平
方案
≥97% (HPLC)
表单
lyophilized solid
效能
80 nM IC50
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
desiccated (hygroscopic)
溶解性
water: 5 mg/mL
运输
ambient
储存温度
−20°C
一般描述
A synthetic peptide containing the calmodulin binding site (290-309) and the autophosphorylation site (Thr286) of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II by blocking Ca2+/calmodulin activation (IC50 = 80 nM) and enzyme-active site (IC50 = 2 µM).
A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr286 by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC50 = 80 nM) by blocking Ca2+/calmodulin activation and enzyme active site (IC50 = 2 µM).
生化/生理作用
Cell permeable: no
Product does not compete with ATP.
Reversible: no
包装
Yes
警告
Toxicity: Standard Handling (A)
序列
H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
其他说明
Waxham, M.N., et al. 1993. Biochemistry32, 2923.
Waxham, M.N., et al. 1993. Brain Res. 609, 1.
Fukunaga, K., et al. 1990. J. Neurochem.54, 103.
Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.
Waxham, M.N., et al. 1993. Brain Res. 609, 1.
Fukunaga, K., et al. 1990. J. Neurochem.54, 103.
Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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