205548
Caffeine
≥99% (HPLC), central nervous system stimulant, solid
别名:
Caffeine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
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关于此项目
经验公式（希尔记法）:
C8H10N4O2
化学文摘社编号:
分子量:
194.19
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Caffeine, Trimethylated xanthine that acts as a potent central nervous system stimulant.
SMILES string
[n]1(c2c(nc1)N(C(=O)N(C2=O)C)C)C
InChI
1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
InChI key
RYYVLZVUVIJVGH-UHFFFAOYSA-N
description
Merck USA index - 14, 1636
assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
chloroform: 50 mg/mL
shipped in
ambient
storage temp.
10-30°C
Quality Level
Disclaimer
Toxicity: Harmful (C)
Other Notes
Zhen, W., and Vaugha, A. T. 1995. Radiat. Res.141, 170.
Howell, L. L. 1993. Cancer Res.54, 4993.
Traganos, F., et al. 1993. Cancer Res.53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.
Howell, L. L. 1993. Cancer Res.54, 4993.
Traganos, F., et al. 1993. Cancer Res.53, 4613.
Zahradnik, I., and Palade, P. 1993. Pflugers Arch. 424, 129.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Biochem/physiol Actions
Cell permeable: no
Primary Target
Potent central nervous system stimulant
Potent central nervous system stimulant
Product does not compete with ATP.
Reversible: no
General description
Trimethylated xanthine that acts as a potent central nervous system stimulant. At higher doses, produces tachycardia and interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by Camptothecin (Cat. No. 208925 ) and topotecan in HL-60 cells.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
法规信息
监管及禁止进口产品
此项目有
Han Hu et al.
Cardiovascular research, 116(5), 944-955 (2019-08-03)
The elevated expression of phospholamban (PLB) has been observed in heart failure and cardiac remodelling, inhibiting the affinity of Ca2+ pump to Ca2+ thereby impairing heart relaxation. However, the mechanisms underlying the regulation of PLB remains to be further studied.
Kurtis Stefan et al.
BMC genomics, 24(1), 253-253 (2023-05-12)
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