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Merck
CN

205530

CA-074

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

CA-074

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关于此项目

经验公式（希尔记法）:
C18H29N3O6
分子量:
383.44
NACRES:
NA.77
UNSPSC Code:
12352200

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产品名称

CA-074, CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

colorless to white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

主要靶标
组织蛋白酶B
产物不与ATP竞争。
可逆：否
细胞渗透性：否
靶标IC50：2.24 nM，对于大鼠肝组织蛋白酶B

Disclaimer

毒性：标准处理（A）

General description

体内和体外有效，不可逆的组织蛋白酶B抑制剂（大鼠肝组织蛋白酶B的IC50=2.24 nM）。
一种环氧琥珀酰肽，可作为组织蛋白酶B的有效、不可逆和特异性抑制剂（大鼠肝组织蛋白酶B的IC50=2.24 nM）。减少缺血诱导的神经元死亡。与CA-074 Me（目录编号205531）相比，表现出较低的膜渗透性。

Other Notes

Chan, V.J., et al. 1999.Biochem.J. 340, 113.
Tsuchiya, K., et al. 1999.Exp.Neurol.155, 187.
Yamamoto, A., et al. 1997.J. Biochem.121, 974.
Inubushi, T., et al. 1994.J. Biochem.116, 282.
Murata, M., et al. 1991.FEBS Lett.280, 307.
Towatari, T., et al. 1991.FEBS Lett.280, 311.

Preparation Note

复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

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