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质量水平
检测方案
≥99% (TLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
white
运输
ambient
储存温度
−20°C
InChI
1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1
InChI key
FPVUCBMBMUHRDX-XMMPIXPASA-N
一般描述
A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G1/S and G2/M transitions. Inhibits p34cdk1/cyclinB (Cdk1; IC50 = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.
生化/生理作用
Cell permeable: yes
Primary Target
p34cdk1/cyclinB
p34cdk1/cyclinB
Product does not compete with ATP.
Reversible: no
Target IC50: 680 nM against Cdk1
警告
Toxicity: Standard Handling (A)
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
Kitagawa, M., et al. 1994. Oncogene 9, 2549.
Kitagawa, M., et al. 1993. Oncogene 8, 2425.
Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
Kitagawa, M., et al. 1994. Oncogene 9, 2549.
Kitagawa, M., et al. 1993. Oncogene 8, 2425.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Alessia Oppezzo et al.
Cell & bioscience, 13(1), 115-115 (2023-06-25)
Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) niche, which includes bone-forming and bone-resorbing cells, i.e., osteoblasts (OBs) and osteoclasts (OCs). OBs originate from mesenchymal progenitors, while OCs are derived from HSCs. Self-renewal, proliferation and differentiation of HSCs
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