203729
(+)-Brefeldin A，来源于布雷正青霉菌
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function.
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别名:
(+)-Brefeldin A，来源于布雷正青霉菌, 1,6,7,8,9,11a,12,13,14,14a-十氢-1,13-二羟基-6-甲基-4H-环戊[f]氧杂环十三烷-4-酮（布雷非德菌素 A）
经验公式（希尔记法）:
C16H24O4
推荐产品
质量水平
检测方案
≥95% (HPLC)
形式
crystalline solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
溶解性
methanol: 2 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15-/m0/s1
InChI key
KQNZDYYTLMIZCT-PNFJWZTBSA-N
一般描述
特异且可逆地阻断蛋白质从内质网（ER）向高尔基体转运，而不影响内吞或溶酶体功能。HDL介导的胆固醇外流的抑制剂。<40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Also available as a 25 mM solution in DMSO (Cat. No. 500583可导致多种哺乳动物细胞中的高尔基体解体和ER肿胀。
特异且可逆地阻断蛋白质从内质网（ER）向高尔基体转运，而不影响内吞或溶酶体功能。HDL介导的胆固醇外流的抑制剂。<40 ng/ml可导致多种哺乳动物细胞中的高尔基体解体和ER肿胀。抑制鸟嘌呤核苷酸交换蛋白BIG1和BIG2对ADP-核糖基化因子的活性。阻止ADP-核糖基化因子与高尔基体结合，抑制GDP-GTP交换。
生化/生理作用
主要目的
阻断蛋白质从内质网（ER）向高尔基体转运
阻断蛋白质从内质网（ER）向高尔基体转运
产品不与ATP竞争。
可逆性：是
细胞渗透性：否
警告
毒性：有害（C）
重悬
溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存2个月。
其他说明
Yamagi, R., et al. 2000.Proc.Natl.Acad.Sci. USA 97, 2567.
Moriango, N., et al. 1996.Proc.Natl.Acad.Sci. USA 93, 12856.
Mendez, A.J.1995.J. Biol. Chem. 270, 5891.
Ridgway, N.D., et al. 1995.J. Biol. Chem. 270, 8023.
Tsai, S.C., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3063.
Ktistakis, N.Y., et al. 1992.Nature356, 344.
Moriango, N., et al. 1996.Proc.Natl.Acad.Sci. USA 93, 12856.
Mendez, A.J.1995.J. Biol. Chem. 270, 5891.
Ridgway, N.D., et al. 1995.J. Biol. Chem. 270, 8023.
Tsai, S.C., et al. 1994.Proc.Natl.Acad.Sci. USA91, 3063.
Ktistakis, N.Y., et al. 1992.Nature356, 344.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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