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Merck
CN
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文件

203401

Millipore

Bleomycin Sulfate, Streptomyces verticillus

Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission.

别名:

Bleomycin Sulfate, Streptomyces verticillus

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About This Item

CAS号:
9041-93-4
MDL编号:
MFCD00070310
UNSPSC代码:
12352200

质量水平

100

检测方案

≥90% (A₂ + B₂, HPLC)

形式

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white to off-white

溶解性

water: 20 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1

InChI key

WUIABRMSWOKTOF-OCBSMOPSSA-N

一般描述

A mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An antineoplastic agent capable of mimicking apoptosis. Useful in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.
Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas.

生化/生理作用

Potency: 1.5-2.0 U/mg

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

重悬

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C.

其他说明

Tounekki, O., et al. 1994. Bull. Cancer 81, 1043.
Chauvergne, J., et al. 1993. Bull. Cancer 80, 70.
Ikeda, S., et al. 1991. Anal. Biochem.192, 96.
Hait, W.N., et al. 1990. Cancer Res.50, 6636.
Arkin, H., et al. 1989. Cancer Res.49, 6556.
Wu, J.C., et al. 1983. J. Biol. Chem.258, 4694.
Takita, T., et al. 1968. Antibiotics21, 79.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H340,H351,H361fd

危险分类

Carc. 2 - Muta. 1B - Repr. 2

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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