203391
(−)-Blebbistatin
≥98% (HPLC), solid, ATPase inhibitor, Calbiochem®
别名:
(-)-Blebbistatin
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关于此项目
经验公式（希尔记法）:
C18H16N2O2
化学文摘社编号:
分子量:
292.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
(-)-Blebbistatin, The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
SMILES string
N2(CC[C@@]3(C2=Nc4c(cc(cc4)C)C3=O)O)c1ccccc1
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChI key
LZAXPYOBKSJSEX-GOSISDBHSA-N
assay
≥98% (HPLC)
form
solid
potency
2 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
methanol: 1.5 mg/mL
100% DMSO: 100 mg/mL
90% DMSO: 75 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Preparation Note
复溶后，等分并冷冻保存（-20°C）。储备液在90%DMSO或甲醇（-20°C）中可稳定长达1个月。100%DMSO中的储备溶液不稳定；临用前复溶。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Biochem/physiol Actions
产物不与ATP竞争。
可逆性：是
细胞可渗透性：是
Disclaimer
毒性：有害 & 致癌/致畸性（E）
General description
（±）-blebbistatin（目录编号203390）的活性对映体，其对ATP酶（IC50 = ~2 µM）和肌球蛋白II依赖性细胞过程具有抑制活性。还报道了强效抑制表达的平滑肌肌球蛋白IIA（SMA）和平滑肌肌球蛋白IIB（SMB）平滑肌肌球蛋白II重链亚型的肌动球蛋白ATP酶活性（IC50 ~3 µM）。
Other Notes
Eddinger, T.J. et al. 2007.J. Pharmacol.Exp.Ther.320, 865.
Shu, S., et al. 2005.Proc.Natl.Acad.Sci. USA102, 1472.
Kovacs, M., et al. 2004.J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003.Science299, 1743.
Shu, S., et al. 2005.Proc.Natl.Acad.Sci. USA102, 1472.
Kovacs, M., et al. 2004.J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003.Science299, 1743.
Packaging
用惰性气体包装
存储类别
11 - Combustible Solids
wgk
WGK 3
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