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Merck
CN
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主要文件

203303

Sigma-Aldrich

Bisindolylmaleimide V

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM).

别名:

Bisindolylmaleimide V, 2,3- bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045, 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045

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About This Item

经验公式（希尔记法）:
C21H15N3O2
CAS号:
113963-68-1
分子量:
341.36
UNSPSC代码:
12352200

质量水平

100

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

red-orange

溶解性

DMSO: 10 mg/mL
methanol: 5 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C21H15N3O2/c1-24-20(25)18(14-10-22-16-8-4-2-6-12(14)16)19(21(24)26)15-11-23-17-9-5-3-7-13(15)17/h2-11,22-23H,1H3

InChI key

SWAWYMIKGOHZMR-UHFFFAOYSA-N

一般描述

A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6kin vivo (IC50 8 µM).
A cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 µM). Blocks the activation of p70s6k/p85s6kin vivo (IC50 = 8 µM).

生化/生理作用

Cell permeable: yes
Primary Target
Negative control compound for protein kinase C inhibition
Product does not compete with ATP.
Reversible: no
Target IC50: >100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo

警告

Toxicity: Standard Handling (A)

其他说明

Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Stephen R Reeves et al.
Experimental physiology, 92(6), 1057-1066 (2007-08-07)
Protein kinase C (PKC) is a broadly expressed and critically important signalling protein with a wide range of functional roles, including central components of respiratory control. For example, systemic and targeted administration of PKC inhibitors within the nucleus of the

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