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Merck
CN
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文件

203293

Sigma-Aldrich

Bisindolylmaleimide I

InSolution, ≥95%, protein kinase C (PKC) inhibitor

别名:

InSolution Bisindolylmaleimide I, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850

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About This Item

经验公式（希尔记法）:
C25H24N4O2
CAS号:
133052-90-1
分子量:
412.48
MDL编号:
MFCD00236428
UNSPSC代码:
12352111
NACRES:
NA.77

质量水平

100

检测方案

≥95% (HPLC)

形式

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

运输

wet ice

储存温度

−20°C

InChI

1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)

InChI key

QMGUOJYZJKLOLH-UHFFFAOYSA-N

一般描述

A highly selective cell-permeable protein kinase C (PKC) inhibitor (Ki = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα, βI, βII, γ, δ, and ε isozymes. May inhibit protein kinase A at a much higher concentration (Ki = 2 µM). Also inhibits telomerase A treated NPC-076 cells. A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.

生化/生理作用

Cell permeable: yes
Primary Target
PKC
Product competes with ATP.
Reversible: yes
Target Ki: 10 nM against PKC

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

外形

A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203290) in anhydrous DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun.241, 730.
Gekeler, V., et al. 1996. Br. J. Cancer74, 897.
Kiss, Z., et al. 1995. Biochim. Biophys. Acta1265, 93.
Muid, R.E., et al. 1991. FEBS Lett.293, 160.
Toullec, D., et al. 1991. J. Biol. Chem.266, 15771.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

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