203291
Bisindolylmaleimide I, Hydrochloride
An enhanced water-soluble form of Bisindolylmaleimide I.
别名:
Bisindolylmaleimide I, Hydrochloride, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
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关于此项目
经验公式（希尔记法）:
C25H24N4O2 · xHCl
化学文摘社编号:
分子量:
412.48 (free base basis)
UNSPSC Code:
12352111
NACRES:
NA.77
MDL number:
产品名称
Bisindolylmaleimide I, Hydrochloride, An enhanced water-soluble form of Bisindolylmaleimide I.
SMILES string
Cl.N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([n](c2)CCCN(C)C)cccc3
InChI
1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H
InChI key
XRAMWNCMYJHGGH-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
orange-red
solubility
water: 10 mg/mL
DMSO: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
Protein kinase C
Protein kinase C
Product competes with ATP.
Reversible: yes
Target Ki: 10 nM against protein kinase C
Disclaimer
Toxicity: Standard Handling (A)
General description
A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). Inhibits protein kinase A at much higher concentrations (Ki = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290 ). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).
Other Notes
Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
K J Christopher et al.
The Journal of physiology, 515 ( Pt 2), 511-522 (1999-03-02)
1. During development, embryos of the pulmonate gastropod, Helisoma trivolvis, undergo a rotation behaviour due to the co-ordinated beating of three bands of ciliated epithelial cells. This behaviour is in part mediated by the neurotransmitter serotonin (5-HT) released from a
Stephen R Reeves et al.
Experimental physiology, 92(6), 1057-1066 (2007-08-07)
Protein kinase C (PKC) is a broadly expressed and critically important signalling protein with a wide range of functional roles, including central components of respiratory control. For example, systemic and targeted administration of PKC inhibitors within the nucleus of the
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