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Merck
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主要文件

197345

Sigma-Aldrich

BCL6抑制剂,79-6

The BCL6 Inhibitor, 79-6 controls the biological activity of BCL6. This small molecule/inhibitor is primarily used for Cancer applications.

别名:

BCL6抑制剂,79-6

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About This Item

经验公式(希尔记法):
C15H9BrN2O6S2
分子量:
457.28
UNSPSC代码:
12352200
NACRES:
NA.28

质量水平

方案

≥95% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

dark red

溶解性

DMSO: 50 mg/mL

运输

ambient

储存温度

2-8°C

一般描述

一种细胞可渗透的羟吲哚化合物,可选择性抑制BCL6的转录抑制活性(在基于293T的报告基因分析中,在50 µM时抑制约70%),但不是其他三个BTB/POZ(bric-a-brac tramtrack broad Complex/痘病毒锌指)家族成员Kaiso,HIC1和PLZF,通过BTB结构域直接BCL6结合(Kd = 138 µM)并阻断辅阻遏物BBD-(BCL6结合域)介导BCL6相互作用(IC50 = 212 µM & Ki = 147 µM,与SMRT-BBD肽竞争性结合),导致BCL依赖性DLBCL(弥漫性大B细胞淋巴瘤)中BCL6靶基因上调,但不依赖BCL的Toledo和OCI-Ly4细胞系。在体外显示出对DLBCL细胞系(IC50为24至936 µM)以及原代人DLBCL细胞的抗增殖活性,并在体内抑制小鼠中BCL依赖性肿瘤的生长(第9天为对照肿瘤大小的<40%;50 mg/kg/天,通过i.p.)。

包装

用惰性气体包装

警告

毒性:标准处理(A)

重悬

复溶后,等分并冷冻保存(-20°C)。储备液在-20°C条件下可稳定保存3个月。

其他说明

Cerchietti, L.C., et al. 2010.Cancer Cell17, 400.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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