(±)-Bay K 8644

A synthetic dihydropyridine derivative that is an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Primary Target
L-type Ca2+ channel

Toxicity: Irritant (B)

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.

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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany