product name
Bay 11-7082, The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
质量水平
检测方案
≥98% (HPLC)
形式
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
off-white
溶解性
DMSO: 200 mg/mL
运输
ambient
储存温度
2-8°C
InChI
1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
InChI key
DOEWDSDBFRHVAP-KRXBUXKQSA-N
一般描述
潜在抗炎药。选择性和不可逆地抑制TNFα诱导的IκBα磷酸化（IC50 = 10 µ M），而不影响组成型IκB-α 磷酸化。减少NFκB的核易位并抑制TNFα诱导的内皮-白细胞粘连分子E-选择素、VCAM-1和ICAM-1的表面表达。E-选择素的抑制作用是不可逆的（IC50 ~10 µM）。还可以可逆地增加p38激酶和JNK-1的活性，并刺激130-140 kDa蛋白的酪氨酸磷酸化。
选择性和不可逆地抑制TNFα诱导的IκBα磷酸化（IC50 = 10 µ M）的潜在抗炎药，导致NF-κB和粘连分子的表达降低。不影响组成型IκBα自磷酸化。抑制TNFα诱导的内皮-白细胞粘连分子E-选择素、VCAM-1和ICAM-1的表面表达。还提供了100 mM（10 mg/483 µl）BAY 11-7082（目录编号196871）的DMSO溶液。
生化/生理作用
主要靶标
TNF-α诱导的IκB磷酸化α
TNF-α诱导的IκB磷酸化α
可逆：否
细胞可渗透性：是
靶标IC50：10 µM，抑制TNF-α-诱导的IκB磷酸化α
包装
用惰性气体包装
警告
毒性：标准处理（A）
重悬
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
其他说明
Kamthong PJ. and Wu, M-C. 2001.Biochem.J. 356.
Izban, K.F., et al. 2000.Hum.Pathol.31, 1482.
Pierce, J.W., et al. 1997.J. Biol. Chem. 272, 21096.
Izban, K.F., et al. 2000.Hum.Pathol.31, 1482.
Pierce, J.W., et al. 1997.J. Biol. Chem. 272, 21096.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
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