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质量水平
检测方案
≥90% (TLC)
形式
solid
反应适用性
reagent type: chelator
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
light yellow
溶解性
DMSO: 10 mg/mL
运输
ambient
储存温度
−20°C
InChI
1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChI key
YJIYWYAMZFVECX-UHFFFAOYSA-N
相关类别
一般描述
BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。消除维生素D3诱导的细胞内Ca2+增加。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。
BAPTA膜透过形式。可以加载到各种各样的细胞中，在其中它被胞质酯酶水解，并作为活性螯合剂BAPTA捕获在细胞内。防止可卡因引起的心室纤颤。诱导蛋白激酶C失活。还抑制毒胡萝卜素诱导的大鼠胸腺细胞凋亡。
应用
- TRPV1-Dependent Antiproliferative Activity of Dioecious Maclura pomifera Extracts in Estrogen Receptor-Positive Breast Cancer Cell Lines Involves Multiple Apoptotic Pathways.: This study explores how BAPTA/AM, a calcium chelator, contributes to the antiproliferative effects by regulating TRPV1 and apoptotic pathways in breast cancer cells (Rumpa et al., 2024).
- Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial calcium-mediated renal tubular cell senescence.: The research highlights BAPTA/AM′s role in mitigating mitochondrial calcium overload, which is linked to cellular senescence and aging processes in renal cells (Xiong et al., 2024).
- TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.: This article discusses the role of BAPTA/AM in the modulation of TRPV3 channels, leading to enhanced lipolysis and protection against obesity through the NRF2/FSP1 pathway (Hu et al., 2024).
- Inflammation and Acinar Cell Dual-Targeting Nanomedicines for Synergistic Treatment of Acute Pancreatitis via Ca(2+) Homeostasis Regulation and Pancreas Autodigestion Inhibition.: BAPTA/AM is utilized to regulate calcium homeostasis, thereby preventing inflammation and autodigestion in acute pancreatitis treatments (Wang et al., 2024).
- IP(3)R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells.: This study investigates how BAPTA/AM inhibits IP3R-mediated calcium release, thereby reducing ferroptotic cell death in neuroblastoma cells (Campos et al., 2024).
包装
用惰性气体包装
警告
毒性：刺激性（B）
重悬
复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备液可在-20°C最长稳定1个月。
其他说明
Bissonnette, M., et al. 1994.Am. J. Physiol.267, G465.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
Jiang, S., et al. 1994.Exp.Cell Res.212, 84.
Billman, G.E.1993.Am. J. Physiol.265, H1529.
Dieter, P., et al. 1993.Biol. Chem. Hoppe Seyler 374, 171.
Harrison, S.M., and Bers, D.M.1987.Biochim.Biophys.Acta 925, 133.
Harrison, S.M., and Bers, D.M.1987.J. Biophys.51, 102A.
Marban, E., et al. 1986.J. Clin. Invest.78, 1185.
Tsien, R.Y.1981.Nature290, 527.
Tsien, R.Y.1980.Biochemistry19, 2396.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Sarah M Zych et al.
Cell reports, 39(7), 110823-110823 (2022-05-19)
Substantia nigra pars compacta (SNc) dopamine neurons play a key role in regulating the activity of striatal circuits within the basal ganglia. In addition to dopamine, these neurons release several other transmitters, including the major inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Javier Campos-Gómez et al.
American journal of physiology. Lung cellular and molecular physiology, 324(4), L493-L506 (2023-02-23)
The coronavirus disease (COVID-19) pandemic, caused by SARS-CoV-2 coronavirus, is devastatingly impacting human health. A prominent component of COVID-19 is the infection and destruction of the ciliated respiratory cells, which perpetuates dissemination and disrupts protective mucociliary transport (MCT) function, an
Beatriz Cristovao et al.
Microbiology spectrum, 11(5), e0123823-e0123823 (2023-09-21)
Phagolysosomes are crucial organelles during the elimination of pathogens by host cells. The maintenance of their membrane integrity is vital during stressful conditions, such as during Candida albicans infection. As the fungal hyphae grow, the phagolysosome membrane expands to ensure
Yanhong Yao et al.
Pharmaceuticals (Basel, Switzerland), 16(1) (2023-01-22)
GLUT4 is an important glucose transporter, which is closely related to insulin resistance and type 2 diabetes. In this study, we investigated the mechanism of Estradiol Dipropionate (EDP) on uptake of glucose in L6 skeletal muscle cells. In our study
Dibyadeep Datta et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(6), 920-932 (2021-04-09)
The etiology of sporadic Alzheimer's disease (AD) requires non-genetically modified animal models. The relationship of tau phosphorylation to calcium-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) dysregulation was analyzed in aging rhesus macaque dorsolateral prefrontal cortex (dlPFC) and rat primary cortical
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