196322
Baicalein
A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50= 120 nM) and reverse transcriptase.
别名:
Baicalein, 5,6,7-Trihydroxyflavone
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关于此项目
经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
分子量:
270.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Baicalein, A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50= 120 nM) and reverse transcriptase.
SMILES string
O1c2c(c(c(c(c2)O)O)O)C(=O)C=C1c3ccccc3
InChI
1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChI key
FXNFHKRTJBSTCS-UHFFFAOYSA-N
description
Merck USA index - 14, 942
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
yellow
solubility
DMSO: 20 mg/mL
acetone: soluble
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
12-lipoxygenase
12-lipoxygenase
Product does not compete with ATP.
Reversible: no
Target IC50: 120 nM against 12-lipoxygenase
Disclaimer
Toxicity: Irritant (B)
General description
A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
Other Notes
Leabeau, A., et al. 2001. Neuroreport12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull.38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun.105, 1090.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull.38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun.105, 1090.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ichitaro Abe et al.
Developmental cell, 57(23), 2623-2637 (2022-12-07)
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-derived linoleic acid triggers
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