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Merck
CN
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主要文件

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安全信息

196000

Sigma-Aldrich

Bafilomycin A1

from Streptomyces griseus, ≥90% (HPLC), film, V-ATPase inhibitor, Calbiochem

别名:

巴弗洛霉素A1，灰色链霉菌

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About This Item

经验公式（希尔记法）:
C35H58O9
CAS号:
88899-55-2
分子量:
622.83
MDL编号:
MFCD06795130
UNSPSC代码:
12352200
NACRES:
NA.77

产品名称

巴弗洛霉素A1，灰色链霉菌, Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.

质量水平

100

方案

≥90% (HPLC)

表单

film

保质期

3 yr

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

溶解性

DMSO: 100 μM
ethanol: soluble

储存温度

−20°C

SMILES字符串

O1[C@@H]([C@H]([C@@H](C[C@]1(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)\C(=C\C(=C\[C@H]([C@H]([C@H](C\C(=C\C=C\[C@@H]2OC)\C)C)O)C)\C)\OC)C)C)O)C)C(C)C

InChI

1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1

InChI key

XDHNQDDQEHDUTM-JQWOJBOSSA-N

一般描述

一种大环内酯类抗生素，可作为液泡型H+-ATP酶（V型； Ki = 500 pM）的特异性抑制剂。区分不同类型ATP酶的有价值的工具。阻断巨噬细胞溶酶体胆固醇的转运，干扰脑细胞的pH调节。在细胞活力测定中，对多种细胞具有细胞毒性作用。据报道，可选择性地抑制β-分泌酶，这是一种参与淀粉样蛋白前体蛋白（APP）加工的酶。HPLC法测定纯度为97％的InSolution形式，也提供≥90％ DMSO溶液（目录号508409）提供。
注意：1套 = 3 x 10 µg

生化/生理作用

主要靶标
空泡型H+ ATP酶

警告

毒性：致癌/致畸（D）

重悬

溶解后，等分并冷冻保存（-20°C）。DMSO储备溶液在-20°C下可稳定保存1年。

其他说明

Sinha, S., and Lieberburg, I. 1999.Proc.Natl.Acad.Sci. USA96, 11049.
Calvert, C.M., and Sanders, D. 1995.J. Biol. Chem.270, 7272.
Nishihara, T., et al. 1995.Biochem.Biophys.Res. Commun.269, 255.
Crider, B.P., et al. 1994.J. Biol. Chem.269, 17379.
Palokangas, H., et al. 1994.J. Biol. Chem.269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994.J. Bone Miner.Res.9, 1575.
Drose, S., et al. 1993.Biochemistry32, 3902.
Furuchi, T., et al. 1993.J. Biol. Chem.268, 27345.
Bowman, E.J., et al. 1988.Proc.Natl.Acad.Sci. USA85, 7972.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

监管及禁止进口产品

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