推荐产品
应用
适合用作丝氨酸/苏氨酸特异性蛋白磷酸酶的抑制剂。
质量
在激酶测定中常规评估为抑制剂。
储存及稳定性
冻干:在4°C下可保存2年;再水化:在-20°C下可保存6个月
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语:
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
法规信息
高风险级别生物产品--毒素类产品
The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
The Biochemical Journal, 262, 69-75 (1989)
Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Molecular and cellular biology, 14, 5881-5890 (1994)
Okadaic acid. Protein phosphatase inhibition and muscle contractile effects.
Journal of Muscle Research and Cell Motility, 9, 563-565 (1988)
The Journal of biological chemistry, 271(33), 20126-20131 (1996-08-16)
Mammalian ribonucleotide reductase is a highly regulated activity essential for DNA synthesis and repair. The 3'-untranslated region (3'-UTR) of mammalian ribonucleotide reductase R2 mRNA has been implicated in the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate-mediated stabilization of mouse BALB/c 3T3 R2 message. We
The Journal of biological chemistry, 270(48), 28654-28659 (1995-12-01)
The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60v-src, directs its cellular trafficking and negatively regulates its kinase activity. Here we report that the serine/threonine phosphatase inhibitor, okadaic acid, destabilized the
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