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此商品 | S5921 | S4400 | 569397 |
|---|---|---|---|
| Quality Level 100 | Quality Level 300 | Quality Level 300 | Quality Level 100 |
| manufacturer/tradename Upstate® | manufacturer/tradename - | manufacturer/tradename - | manufacturer/tradename Calbiochem® |
| technique(s) activity assay: suitable (kinase) | technique(s) - | technique(s) - | technique(s) - |
一般描述
适合用作体外和培养细胞中的 PKC 以及其他蛋白激酶的有效抑制剂。
应用
星状孢菌素已被用作蛋白激酶抑制剂，在蛋白水平上研究了泛素蛋白连接酶E3组分N-识别蛋白5 (UBR5)介导的CDC73调控。十字孢碱已被用于诱导CHO-K1细胞系的凋亡，随后进行细胞成像和细胞裂解物提取以便进一步分析。[1]
生化/生理作用
星状孢菌素是一种广谱蛋白激酶抑制剂，属于吲哚卡巴唑家族。它被称为典型的ATP竞争性激酶抑制剂。星状孢菌素对各种癌症都有效。它通常用于诱导不同类型细胞的凋亡。
质量
通过蛋白激酶抑制分析进行了常规评估
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Aquatic Chronic 4 - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
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Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of events that eventually lead
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Electrophysiological experiments in our laboratory have led to the discovery that the cholinergic neurons in the nucleus basalis in the rat forebrain possess constitutively active inward rectifier K(+) channels. Unlike cloned inward rectifier K(+) channels, these constitutively active inward rectifier
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The loss of cell volume or cell shrinkage, termed apoptotic volume decrease (AVD), is a classical characteristic of apoptosis. Microscopy, Coulter electronic sizing, and/or flow cytometry has traditionally been the means to measure this characteristic of apoptosis. Although electronic cell
Staurosporine: a prototype of a novel class of inhibitors of tumor cell invasion?
C A O'Brian et al.
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