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Merck
CN
所有图片(1)

主要文件

安全信息

19-123-M

Sigma-Aldrich

星状孢子素

Staurosporine Streptomyces is a potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases.

别名:

PKC inhibitor, protein kinase C inhibitor

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About This Item

UNSPSC代码:
12352200
eCl@ss:
32160405
NACRES:
NA.41

质量水平

制造商/商品名称

Upstate®

技术

activity assay: suitable (kinase)

一般描述

适合用作体外和培养细胞中的 PKC 以及其他蛋白激酶的有效抑制剂。

应用

星状孢菌素已被用作蛋白激酶抑制剂,在蛋白水平上研究了泛素蛋白连接酶E3组分N-识别蛋白5 (UBR5)介导的CDC73调控。十字孢碱已被用于诱导CHO-K1细胞系的凋亡,随后进行细胞成像和细胞裂解物提取以便进一步分析。

生化/生理作用

星状孢菌素是一种广谱蛋白激酶抑制剂,属于吲哚卡巴唑家族。它被称为典型的ATP竞争性激酶抑制剂。星状孢菌素对各种癌症都有效。它通常用于诱导不同类型细胞的凋亡。

质量

通过蛋白激酶抑制分析进行了常规评估

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard

警示用语:

Warning

危险声明

危险分类

Aquatic Chronic 4 - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Boyang Chen et al.
Bioelectrochemistry (Amsterdam, Netherlands), 153, 108456-108456 (2023-05-30)
Lower yields and poorer quality of biopharmaceutical products result from cell death in bioreactors. Such cell death is commonly associated with programmed cell death or apoptosis. During apoptosis, caspases are activated and cause a cascade of events that eventually lead
Yasuko Nakajima et al.
Methods in enzymology, 484, 613-630 (2010-11-03)
Electrophysiological experiments in our laboratory have led to the discovery that the cholinergic neurons in the nucleus basalis in the rat forebrain possess constitutively active inward rectifier K(+) channels. Unlike cloned inward rectifier K(+) channels, these constitutively active inward rectifier
Carl D Bortner et al.
Methods in enzymology, 428, 161-181 (2007-09-19)
The loss of cell volume or cell shrinkage, termed apoptotic volume decrease (AVD), is a classical characteristic of apoptosis. Microscopy, Coulter electronic sizing, and/or flow cytometry has traditionally been the means to measure this characteristic of apoptosis. Although electronic cell
Joachim Rudolph et al.
The Enzymes, 34 Pt. B, 157-180 (2013-01-01)
The p21-activated kinases (PAKs) are Ser/Thr kinases in the STE20 kinase family with important roles in regulating cytoskeletal organization, cell migration, and signaling. The PAK enzyme family comprises six members subdivided into two groups: Group I, represented by PAK1, 2
Staurosporine: a prototype of a novel class of inhibitors of tumor cell invasion?
C A O'Brian et al.
Journal of the National Cancer Institute, 82(22), 1734-1735 (1990-11-21)

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