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Merck
CN
所有图片(2)

文件

189826

Sigma-Aldrich

5-氮杂-2′-脱氧胞苷酸

InSolution, ≥98%, DNA methyltransferase inhibitor

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所有图片(2)
别名:
InSolution 5-氮杂-2′-脱氧胞苷酸, 地西他滨
经验公式（希尔记法）:
C8H12N4O4
CAS号:
2353-33-5
分子量:
228.21
MDL编号:
MFCD00043011
UNSPSC代码:
12352200
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

liquid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)
protect from light

运输

ambient

储存温度

−20°C

InChI

1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)

InChI key

XAUDJQYHKZQPEU-UHFFFAOYSA-N

一般描述

一种作为DNA甲基转移酶抑制剂的胞嘧啶类似物。在TRAIL抗性细胞系中恢复caspase-8和caspase-10 mRNA和蛋白表达以及TRAIL（肿瘤坏死因子相关凋亡诱导配体）敏感性。也增强HDAC（组蛋白去乙酰化酶）抑制剂诱导的凋亡。另提供该化合物的固体形式（目录号189825）。

包装

用惰性气体包装

警告

毒性：监管审查（Z）

外形

100 mM（10 mg/438 µl）5-氮杂-2ʹ-脱氧胞苷（目录编号189825）的DMSO溶液。

其他说明

Eggert, A., et al. 2001.Cancer Res.61, 1314.
Takebayashi, S., et al. 2001.Biochem.Biophys.Res. Commun.288, 921.
Zhu, W.G., et al. 2001.Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000.Cancer Res.60, 4315.
Haaf, T. 1995.Pharmacol.Ther.65, 19.
Jones, P.A., and Taylor, S.M.1980.Cell20, 85.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H341,H360

危险分类

Muta. 2 - Repr. 1B

WGK

WGK 2

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